The Effect of Xylocarpus granatum J. Koenig Seed Extract Cream on The Number of Fibroblast and Re-Epithelialization in IIA Degree Burn Wound Healing

Burns require a recovery process that multiplies complex biological mechanisms including anti-inflammatory, proliferation, and tissue remodeling. X.granatum J.Koenig (XG) is popular plant grows in the mangrove forest Bali. Traditionally, this used mainly for antiinflammation, dysentery, fever, skin emolliating, wound treatment, abdominal problems. Flavonoids, tannins saponins are active metabolites of plant, which has antioxidant healing effects. IL-1β, IL-6 TNF-α pro-inflammatory cytokines involved pathophysiology wound. Fibroblasts support granulation synthesis, ECM production, collagen synthesis. Re-epithelialization plays role closure. The aim present study to evaluate effectiveness XG extract seeds cream on burn grade IIA mice. was evaluated activity by DPPH method. two formulations were measured physical quality organoleptic, homogeneity, pH. creams from contraction, histological analysis fibroblast proliferation re-epithelialization Statistical analyses performed with post hoc Tukey using variance analyzed Package Social Science (SPSS, Version 26). very strong an IC50 value 7,939 ppm. preparation homogeneous pH 6,5. treatment XGC 15% promote significant increases contraction rate, fibroblasts SSD (p>0,05). These results suggest effective mice increasing re-epithelialization.